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In the limb bud, patterning along the anterior-posterior (A-P) axis is controlled by Sonic Hedgehog (Shh), a signaling molecule secreted by the "Zone of Polarizing Activity", an organizer tissue located in the posterior margin of the limb bud.We have found that the transcription factors GATA4 and GATA6, which are key regulators of cell click here i
Approximately 60% of morphine is glucuronidated to morphine-3-glucuronide (M3G) which may aggravate preexisting pain conditions.Accumulating evidence indicates that M3G signaling through neuronal Toll-like receptor 4 9x11 pergola (TLR4) may be central to this proalgesic signaling event.These events are known to include elevated neuronal excitabilit